IIT Delhi Develops New Drug Development Strategy, Professor V. Haridas from IIT Delhi’s Chemistry Department has led an interdisciplinary research team in developing and testing a new technique for creating therapeutic compounds.
Professor Haridas worked on this project with Professor Guruprasad Medigeshi and Professor Bishwajit Kundu from IIT Delhi’s Kusuma School of Biological Sciences.
In general, drugs are organic chemicals that interact with human molecules. There are a greater number of macromolecules in the body than in the environment. Proteins and nucleic acids constitute these macromolecules.
CART is used to identify a molecule suitable for binding to a protein target. However, this process takes some time. IIT Delhi Develops New Drug
Researchers IIT Delhi Develops New Drug chemistry that is based on macromolecular mimicry. Molecules are shaped in much the same way as objects. Designing and synthesizing molecules with unique shapes is an art. To mimic the macromolecular interaction, the researchers are using tiny molecules.
The compounds that target protein interfaces were created using organic and biophysical methods. These techniques provided a universal scaffold for designing inhibitors. As a result of the universal scaffold, a specific inhibitor can be designed for a specific Protein-Protein Interaction (PPI).
This technique has been applied to create therapeutic compounds for viral encephalitis in Southeast Asian countries, such as JEV, and protein aggregation diseases, such as Alzheimer’s. A medicinal compound developed by the Chemistry Department of IIT Delhi has been patented.
Their new method of designing medications has the potential to treat retrovirus infections.